                         SEQUENCE LISTING

<110>  The Government of the United States of America as 
       represented by the Secretary of the Department of Health and 
       Human Services
       Cuttitta, Frank
       Martinez, Alfredo
       Stetler-Stevenson, William  G.
       Unsworth, Edward J.
       Saavedra, Juan M.
 
<120>  VASOREGULATING COMPOUNDS AND METHODS OF THEIR USE

<130>  4239-66904

<150>  60/416,291
<151>  2002-10-04

<160>  4     

<170>  PatentIn version 3.2

<210>  1
<211>  1449
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (157)..(714)

<400>  1
ctggatagaa cagctcaagc cttgccactt cgggcttctc actgcagctg ggcttggact     60

tcggagtttt gccattgcca gtgggacgtc tgagactttc tccttcaagt acttggcaga    120

tcactctctt agcagggtct gcgcttcgca gccggg atg aag ctg gtt tcc gtc      174
                                        Met Lys Leu Val Ser Val         
                                        1               5               

gcc ctg atg tac ctg ggt tcg ctc gcc ttc cta ggc gct gac acc gct      222
Ala Leu Met Tyr Leu Gly Ser Leu Ala Phe Leu Gly Ala Asp Thr Ala         
            10                  15                  20                  

cgg ttg gat gtc gcg tcg gag ttt cga aag aag tgg aat aag tgg gct      270
Arg Leu Asp Val Ala Ser Glu Phe Arg Lys Lys Trp Asn Lys Trp Ala         
        25                  30                  35                      

ctg agt cgt ggg aag agg gaa ctg cgg atg tcc agc agc tac ccc acc      318
Leu Ser Arg Gly Lys Arg Glu Leu Arg Met Ser Ser Ser Tyr Pro Thr         
    40                  45                  50                          

ggg ctc gct gac gtg aag gcc ggg cct gcc cag acc ctt att cgg ccc      366
Gly Leu Ala Asp Val Lys Ala Gly Pro Ala Gln Thr Leu Ile Arg Pro         
55                  60                  65                  70          

cag gac atg aag ggt gcc tct cga agc ccc gaa gac agc agt ccg gat      414
Gln Asp Met Lys Gly Ala Ser Arg Ser Pro Glu Asp Ser Ser Pro Asp         
                75                  80                  85              

gcc gcc cgc atc cga gtc aag cgc tac cgc cag agc atg aac aac ttc      462
Ala Ala Arg Ile Arg Val Lys Arg Tyr Arg Gln Ser Met Asn Asn Phe         
            90                  95                  100                 

cag ggc ctc cgg agc ttt ggc tgc cgc ttc ggg acg tgc acg gtg cag      510
Gln Gly Leu Arg Ser Phe Gly Cys Arg Phe Gly Thr Cys Thr Val Gln         
        105                 110                 115                     

aag ctg gca cac cag atc tac cag ttc aca gat aag gac aag gac aac      558
Lys Leu Ala His Gln Ile Tyr Gln Phe Thr Asp Lys Asp Lys Asp Asn         
    120                 125                 130                         

gtc gcc ccc agg agc aag atc agc ccc cag ggc tac ggc cgc cgg cgc      606
Val Ala Pro Arg Ser Lys Ile Ser Pro Gln Gly Tyr Gly Arg Arg Arg         
135                 140                 145                 150         

cgg cgc tcc ctg ccc gag gcc ggc ccg ggt cgg act ctg gtg tct tct      654
Arg Arg Ser Leu Pro Glu Ala Gly Pro Gly Arg Thr Leu Val Ser Ser         
                155                 160                 165             

aag cca caa gca cac ggg gct cca gcc ccc ccg agt gga agt gct ccc      702
Lys Pro Gln Ala His Gly Ala Pro Ala Pro Pro Ser Gly Ser Ala Pro         
            170                 175                 180                 

cac ttt ctt tag gatttaggcg cccatggtac aaggaatagt cgcgcaagca          754
His Phe Leu                                                             
        185                                                             

tcccgctggt gcctcccggg acgaaggact tcccgagcgg tgtggggacc gggctctgac    814

agccctgcgg agaccctgag tccgggaggc accgtccggc ggcgagctct ggctttgcaa    874

gggcccctcc ttctgggggc ttcgcttcct tagccttgct caggtgcaag tgccccaggg    934

ggcggggtgc agaagaatcc gagtgtttgc caggcttaag gagaggagaa actgagaaat    994

gaatgctgag acccccggag caggggtctg agccacagcc gtgctcgccc acaaactgat   1054

ttctcacggc gtgtcacccc accagggcgc aagcctcact attacttgaa ctttccaaaa   1114

cctaaagagg aaaagtgcaa tgcgtgttgt acatacagag gtaactatca atatttaagt   1174

ttgttgctgt caagattttt tttgtaactt caaatataga gatatttttg tacgttatat   1234

attgtattaa gggcatttta aaagcaatta tattgtcctc ccctatttta agacgtgaat   1294

gtctcagcga ggtgtaaagt tgttcgccgc gtggaatgtg agtgtgtttg tgtgcatgaa   1354

agagaaagac tgattacctc ctgtgtggaa gaaggaaaca ccgagtctct gtataatcta   1414

tttacataaa atgggtgata tgcgaacagc aaacc                              1449


<210>  2
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Lys Leu Val Ser Val Ala Leu Met Tyr Leu Gly Ser Leu Ala Phe 
1               5                   10                  15      


Leu Gly Ala Asp Thr Ala Arg Leu Asp Val Ala Ser Glu Phe Arg Lys 
            20                  25                  30          


Lys Trp Asn Lys Trp Ala Leu Ser Arg Gly Lys Arg Glu Leu Arg Met 
        35                  40                  45              


Ser Ser Ser Tyr Pro Thr Gly Leu Ala Asp Val Lys Ala Gly Pro Ala 
    50                  55                  60                  


Gln Thr Leu Ile Arg Pro Gln Asp Met Lys Gly Ala Ser Arg Ser Pro 
65                  70                  75                  80  


Glu Asp Ser Ser Pro Asp Ala Ala Arg Ile Arg Val Lys Arg Tyr Arg 
                85                  90                  95      


Gln Ser Met Asn Asn Phe Gln Gly Leu Arg Ser Phe Gly Cys Arg Phe 
            100                 105                 110         


Gly Thr Cys Thr Val Gln Lys Leu Ala His Gln Ile Tyr Gln Phe Thr 
        115                 120                 125             


Asp Lys Asp Lys Asp Asn Val Ala Pro Arg Ser Lys Ile Ser Pro Gln 
    130                 135                 140                 


Gly Tyr Gly Arg Arg Arg Arg Arg Ser Leu Pro Glu Ala Gly Pro Gly 
145                 150                 155                 160 


Arg Thr Leu Val Ser Ser Lys Pro Gln Ala His Gly Ala Pro Ala Pro 
                165                 170                 175     


Pro Ser Gly Ser Ala Pro His Phe Leu 
            180                 185 


<210>  3
<211>  52
<212>  PRT
<213>  Homo sapiens


<220>
<221>  mat_peptide
<222>  (1)..(52)
<223>  Mature adrenomedullin, corresponding to positions 95-146 of 
       preproadrenomedullin (SEQ ID NO: 2)

<400>  3

Tyr Arg Gln Ser Met Asn Asn Phe Gln Gly Leu Arg Ser Phe Gly Cys 
1               5                   10                  15      


Arg Phe Gly Thr Cys Thr Val Gln Lys Leu Ala His Gln Ile Tyr Gln 
            20                  25                  30          


Phe Thr Asp Lys Asp Lys Asp Asn Val Ala Pro Arg Ser Lys Ile Ser 
        35                  40                  45              


Pro Gln Gly Tyr 
    50          


<210>  4
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(12)
<223>  Active peptide AM(11-22), corresponding to positions 11-22 of 
       adrenomedullin (SEQ ID NO: 3) and positions 105-116 of 
       preproadrenomedullin (SEQ ID NO: 2).

<400>  4

Leu Arg Ser Phe Gly Cys Arg Phe Gly Thr Cys Thr 
1               5                   10          


